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RAFTs are... |
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Dr Ritva Tikkanen
c/o
Arbeitsgruppe RAFTs
Institute Of Cell Biology
University Of Bonn
Ulrich-Haberland-Str.61a
D-53121 Bonn
Fon: +49 228 735307
Fax: +49 228 735302
Email: tikkanen@uni-bonn.de
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Born |
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29.01.1969 |
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Varpaisjärvi, Finland |
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Education |
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1976-1985 |
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Basic school education in Varpaisjärvi |
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1985-1988 |
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High School |
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05/1988 |
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Abitur |
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1988-12/91 |
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Studies of biochemistry in the University of Turku |
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05/91-12/91 |
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M.Sc. thesis work (Diplomarbeit) on the purification of human lysosomal aspartylglucosaminidase; in the laoratory of Prof. Leena Peltonen, National Public Health Institute, Helsinki |
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06/94 |
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Master of Science in Biochemistry |
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01/92-03/96 |
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Ph.D. work "Structure, function and intracellular targeting of human lysosomal aspartylgucosaminidase" in the laboratory of Prof. Leena Peltonen |
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03/96 |
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Public Dissertation |
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10/96 |
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Ph.D. degree (University of Helsinki) |
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10/96-9/98 |
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Postdoctoral fellow (EU TMR Program) in the laboratory of Prof. Kurt von Figura, Göttingen, Germany |
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since 10/98 |
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Postdoc/Junior group leader in the laboratory of Prof. Volker Herzog, Bonn, Germany |
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Scientific Awards |
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02/97 |
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Ph.D. thesis was chosen as the best thesis in the Medical Faculty of the University of Helsinki |
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1997 |
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Ph.D. thesis chosen as best thesis of the University of Helsinki in 1996 |
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Publications |
Tikkanen, R., Obermüller, S., Denzer, K., Pungitore R, Geuze , H.J., von Figura, K. and Höning, S. (2000) The dileucine motif within the tail of MPR46 is required for sorting of the receptor in endosomes. Traffic, 1:631-640 |
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Tikkanen, R., Peltola, M., Oinonen, C., Rouvinen, J. and Peltonen, L. (1997) Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase. Embo J, 16, 6684-93. |
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Tikkanen, R., Riikonen, A., Oinonen, C., Rouvinen, J. and Peltonen, L. (1996) Functional analyses of active site residues of human lysosomal aspartylglucosaminidase: implications for catalytic mechanism and autocatalytic activation. Embo J, 15, 2954-60. |
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Tikkanen, R., Rouvinen, J., Torronen, A., Kalkkinen, N. and Peltonen, L. (1996) Large-scale purification and preliminary x-ray diffraction studies of human aspartylglucosaminidase. Proteins, 24, 253-8. |
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Tikkanen, R., Enomaa, N., Riikonen, A., Ikonen, E. and Peltonen, L. (1995) Intracellular sorting of aspartylglucosaminidase: the role of N-linked oligosaccharides and evidence of Man-6-P-independent lysosomal targeting. DNA Cell Biol, 14, 305-12. |
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Oinonen, C., Tikkanen, R., Rouvinen, J. and Peltonen, L. (1995) Three-dimensional structure of human lysosomal aspartylglucosaminidase. Nature Struct Biol, 2, 1102-8. |
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Peltola, M., Tikkanen, R., Peltonen, L. and Jalanko, A. (1996) Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation. Hum Mol Genet, 5, 737-43. |
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Riikonen, A., Tikkanen, R., Jalanko, A. and Peltonen, L. (1995) Immediate interaction between the nascent subunits and two conserved amino acids Trp34 and Thr206 are needed for the catalytic activity of aspartylglucosaminidase. J Biol Chem, 270, 4903-7. |
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Riikonen, A., Rouvinen, J., Tikkanen, R., Julkunen, I., Peltonen, L. and Jalanko, A. (1996) Primary folding of aspartylglucosaminidase. Significance of disulfide bridges and evidence of early multimerization. J Biol Chem, 271, 21340-4. |
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Saarela, J., Laine, M., Tikkanen, R., Oinonen, C., Jalanko, A., Rouvinen, J. and Peltonen, L. (1998) Activation and oligomerization of aspartylglucosaminidase. J Biol Chem, 273, 25320-8. |
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Järvelä, I., Lehtovirta, M., Tikkanen, R., Kyttälä, A. and Jalanko, A. (1999) Defective intracellular transport of CLN3 is the molecular basis of Batten disease (JNCL). Hum Mol Genet, 8, 1091-1098 |
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Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., and Jahn, R. (2000) The R-SNARE endobrevin/VAMP-8 mediates fusion of early and late endosomes. Mol. Biol. Cell 11: 3289-3298 |
Submitted for Publication |
Tikkanen R, Icking A, Wayneck GL and Herzog V (2000) The soluble N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts. Submitted |
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Simmen T, Höning S, Tikkanen R and Hunziker W (2000) The AP-4 adaptor complex is required for basolateral sorting in epithelial cells. Submitted |
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